Important Numbers

  

Tax Identification 060-64-6973
Laboratory License CL-0500
Director Certificate 551
Medicare Certificate 07L0008215
Medicare Provider 690000319
CLIA Laboratory Certificate of Compliance (#07D0706791)
YUPL has been CLIA certified since 1992.

Credentials

Francis P. Gasparro, Ph.D.


Director, Photobiology Laboratory Department of Dermatology & Cutaneous Biology

Thomas Jefferson University
233 South 10th Street Philadelphia, PA 19107 (215) 503-3327, 503-3322 (fax)

E-mail: francis.gasparro@mail.tju.edu (or fotondoc@aol.com)

Education

1962-1966: Villanova University, B.S., Chemistry, May, 1966
1966-1970: Princeton University, Ph.D., Chemistry, June, 1971
Thesis Title Intermolecular Interactions in Solution and Complex Formation: I. Vapor-Solution Equilibria; II. NMR Solvent Effects
 

Appointments

1970-71 Assistant Professor, William Paterson College of NJ
1971-72 Research Staff Associate, Department of Biochemical Sciences, Princeton University
1972-75 Assistant Professor, Department of Chemistry, Wellesley College
1975-77 Lecturer/Research Staff, Department of Biochemical Sciences, Princeton University
1977-80 Assistant Professor, Department of Chemistry, Colgate University
1980-82 Research Staff Associate, Department of Dermatology, Columbia University
1982-85 Associate Research Scientist, Department of Dermatology, Columbia University
1986-89 Associate Research Scientist, Department of Dermatology, Yale University
1989-96 Research Scientist, Departments of Dermatology, Surgery, Yale University
1997- Research Professor, Department of Dermatology, Thomas Jefferson University
(joint: Department of Biochemistry & Molecular Pharmacology)

Research Interests

  • 1. Psoralen-DNA photochemistry, photobiology, and photoimmunology; repair of psoralen-DNA photoadducts; mutagenesis; molecular biology.
  • 2. p53 - its role in phototherapy and mutations in skin cancer
  • 3. Photochemotherapy for the prevention of restenosis after angioplasty
  • 4. Drug delivery systems: photoactivatable antisense DNA, AMT-Insulin.
    •
    1. Photobiology of other relevant biomolecules: sunscreens, adenine, gilvocarcin.
    2. Sunscreen Photobiology
    Books 1. Editor, Psoralen-DNA Photobiology, CRC Uniscience Volume, CRC Press (1988).
    1. Extracorporeal Photochemotherapy, RG Landes Co, Medical Intelligence Unit (1994).
    2. Editor, Sunscreen Photobiology, RG Landes Co, Medical Intelligence Unit (1997).
    Patents 1. Biotinylated Psoralens (U.S. Patent No: 4,868,311; 9/19/89).
    2. Selective Inhibition of Gene Expression by Photoactivatable Oligonucleotides (U.S. Patent No: 5,256,648; 10/26/93).
    3. Specific Immune System Modulation (submitted 11/92).
    4. Inhibition of Smooth Muscle Cell Proliferation by Photoactivated 8-Methoxypsoralen (U.S. Patent No: 5,354,774; 10/11/94).
    5. Immune System Modulation Using Psoralens Activated with Visible Light (U.S. Patent No: 5,462,733; 10/31/95).
    6. Cellular Vaccine and Methods of Use for the Treatment of Solid Tumor Malignancies (U.S. Patent No: 5,820,872; 10/13/98).     TEACHING EXPERIENCE

    Fall 1996 Adjunct Professor of Chemistry, University of New Haven
    1981-1982 Associate Professor, Fordham University
    1977-1980 Assistant Professor, Colgate University
    1976-1977 Lecturer, Department of Biological Sciences, Princeton Univ.
    1976 Summer Lecturer, Minority Program in Chemistry, Princeton University
    1972-1975 Assistant Professor, Wellesley College
    1972 Summer Assistant Professor, Western New Mexico University
    1970-1971 Assistant Professor, Paterson State College of New Jersey
    1966-1970 Graduate student teaching assistant at Princeton University

    COURSES TAUGHT

    Colgate University Wellesley College
    General Chemistry I & II General Chemistry I and II
    Biochemistry Thermodynamics and Kinetics
    Energy and Society Molecular Spectroscopy in Biochemistry
    The Science of Photobiology Foundations of Chemical Research
    The History of DNA The Physical Chemistry of Water

    OTHER FACULTY EXPERIENCE

    Colgate University Wellesley College
    Chairman, Colgate II Board (Independent Study) Computer Users' Committee
    Member, Search Committee for Dean of the Faculty Recorder Search Committee
    University Council Chemistry Department Search Committee,
    Advisor, Chemistry Club Advisor, Photography Club
    Advisor, Ecology House Faculty Associate, Shafer Dormitory

    PARTICIPATION IN EDUCATIONAL MEETINGS

    1. Participant in NSF Chautauqua-type course on the Instructional Uses of Computers in Education, November, 1973 - February, 1974.

    2. Participant in ACS Short Course on Micro-processors and Minicomputers - Interfacing and Applications: Virginia Polytechnic Institute, December 8 - 13, 1974.

    3. Participant in Workshop on Computers in Chemical Education at the ACS 7th Central Regional Meeting, Morgantown, West Virginia, May 28, 1972.
    1. Invited Lecturer - Sunscreen Photobiology - Photobiology Education Symposium -27th Annual Meeting Amrican Society for Photobiology (July 1999)
    PUBLICATIONS I. Original Research Articles

    1. O'Driscoll K & Gasparro FP. Copolymerization. J Macromol Sci Al: 643-650 (1967).

    2. Kuntz ID, Johnston MD, Gasparro FP & Taylor RP. Molecular interactions and the Benesi-Hildebrand equation. J Am Chem Soc 90: 4778-4782 (1968).

    3. Kuntz ID, Johnston MD & Gasparro FP. Nuclear magnetic resonance solvent effects and molecular interactions II. A comparison of dipolar, hydrogen-bonding and charge transfer effects. J Am Chem Soc 91: 5717-5725 (1969).

    4. Gasparro FP & Kochevar IE. Investigation of protriptylene photoproducts which cause cell membrane disruption. Photochem Photobiol 35: 351-356 (1982).

     5. Gasparro FP, Berger CL & Edelson, RL. Effect of monochromatic UVA light and 8-methoxypsoralen on human lymphocyte response to mitogen. Photodermatol 1: 10-17 (1984).

    6. Gasparro FP, Saffran WA, Cantor CR & Edelson RL. Wavelength dependence for AMT crosslinking of pBR322 DNA. Photochem Photobiol 40: 215-219 (1984).

    7. Berger CL, Gasparro FP, Welsh J, Cantor CR, Dervan P, Grant S & Edelson RL. Comparison of synthetic psoralen derivatives and 8-methoxypsoralen in the inhibition of lymphocyte proliferation. Ann NY Acad Sci 454: 80-90 (1985).

    8. Gasparro FP, Bagel J & Edelson RL. HPLC Analysis of 8-MOP photoadducts in calf thymus DNA, poly (dAdT.dAdT), poly(dA.dT) and poly(dT). Photochem Photobiol 42: 98-101 (1985).

    9. Santella RM, Dharmaraja N, Gasparro FP & Edelson RL. Monoclonal antibodies that recognize 8-MOP modified DNA. Nucl Acids Res 13: 2533-2544 (1985).

    10. Armstrong RB, Whitman GB, Gasparro FP & Leach EE. Potential hazards in phototherapy with ultraviolet radiation arising from variation in dose required to produce erythema. J Am Acad Dermatol 13: 772-777 (1985).

    11. Gasparro FP. UVB-induced photoproducts of para-aminobenzoic acid: Photodermatol 2: 151-157 (1985).

    12. Gasparro FP & Fresco JR. UV-induced 8,8-adenine dehydrodimer formation. Nucl Acids Res 14: 4239-4251 (1986).

    13. Gasparro FP, Yemul SS, Knobler RM & Edelson, RL. Receptor-Mediated Phototoxicity. Synthesis of a photoactivatable psoralen derivative conjugated to Insulin. Biochem Biophys Res Comm 141: 502-509 (1986).

    14. Edelson RL, Berger CL, Gasparro FP et al. Treatment of Cutaneous T Cell Lymphoma by Extracorporeal Photochemotherapy - Preliminary Results. New Engl J Med 316: 297-303 (1987).

    15. Gasparro FP, Knobler RM, Weingold DH, Yemul SS & Edelson RL. Photoactivation of a Psoralen derivative conjugated to insulin. Ann NY Acad Sci 507: 339-340 (1987).

    16. Gasparro FP, Battista J, Song J & Edelson RL. Rapid and sensitive analysis of 8-methoxypsoralen in plasma. J Invest Dermatol 90: 234-236 (1988).

    17. Gasparro FP, Knobler RM, Saffran WA & Edelson RL. Photochemistry of Gilvocarcin: An Anti-tumor Antibiotic. Chem-Biol Interactions 67: 267-274 (1988).

    18. Saffran WA, Welsh J, Gasparro FP, Knobler RM, Cantor CR & Edelson RL. Preparation and Characterization of a Biotinylated Psoralen. Nucl Acids Res 16: 7221-7231 (1988).

    19. Miolo G, Stefanidis M, Santella RM, Dall'Acqua F & Gasparro FP. 6,4,4'-Trimethylangelicin photoadduct formation in DNA: production and characterization of a specific monoclonal antibody. J Photochem and Photobiol 3: 101-112 (1989).

    20. Yang XY, Gasparro FP, DeLeo VA & Santella RM. 8-Methoxypsoralen-DNA photoadducts in patients treated with 8-methoxypsoralen and ultraviolet A light. J Invest Dermatol 92: 59-63 (1989).

     21. Heald PW, Perez MI & Gasparro FP. Dosage guidelines: extracorporeal photochemotherapy (photopheresis). Arch Dermatol 126: 1369 (1990).

    22. Gasparro FP, Dall'Amico R, O'Malley M & Edelson RL. Cell membrane DNA: a new target for psoralen photoadduct formation. Photochem Photobiol 52: 315-321 (1990). (Rapid communication)

    23. Tokura Y, Yagi J, Edelson RL & Gasparro FP. Inhibitory effect of 8-MOP plus UVA on IL-1 production by murine epidermal keratinocytes. Photochem Photobiol 53:517-523 (1991).

    24. Gasparro FP & Edelson RL. Photoactivatable antisense DNA: Suppression of ampicillin resistance in normally resistant E. coli. Antisense Research & Development 1: 117-140 (1991).

    25. Tokura Y, Edelson RL & Gasparro FP. Formation and removal of 8-MOP-DNA photoadducts in keratinocytes: Effects of calcium and retinoids. J Invest Dermatol 96: 942-949 (1991).

    26. Bevilacqua PM, Edelson RL & Gasparro FP. HPLC analysis of 8-methoxypsoralen monoadducts and crosslinks in lymphocytes and keratinocytes. J Invest Dermatol 97: 151-155 (1991).

    27. Maso MJ, AM Ruszlowski, Bauerle J, DeLeo VA & Gasparro FP. Celery phytophotodermatitis in a chef. Arch Dermatol 127: 912-913 (1991).

    28. Baoyoun Y, Gasparro FP, Bevilacqua PM & Santella RM. Quantitation of plasma levels of 8-methoxypsoralen by competitive ELISA. J Invest Dermatol 97: 1001-1004 (1991).

    29. Perez M, Yamane Y, John L, Gasparro FP & Edelson R. DNA associated with the cell membrane is involved in the inhibition of skin rejection response induced by infusions of photodamaged alloreactive cells that mediate rejection of skin allograft. Photochem Photobiol 55 :839-49 (1992).

    30. Tokura Y, Edelson RL & Gasparro FP. Retinoid augmentation of bioactive interleukin-1 products in murine keratinocytes. Br J Dermatol 126:485-495 (1992).

    31. Heald P, Rook A, Perez MI, Wintroub B, Knobler R, Jegasothy B, Gasparro F, Berger C & Edelson R. Treatment of erythrodermic CTCL with photopheresis. J Am Acad Dermatol 27: 427-433 (1992).

    32. Oroskar AA, Gasparro FP & Peak MJ. Relaxation of supercoiled DNA by aminomethyltrimethyl-psoralen and UV photons: action spectrum. Photochem Photobiol 57: 648-654 (1993).

    33. Rousset S, Nocentini S, Santella R, Gasparro F & Moustacchi E. Immunological probing of induction and repair of 8-methoxypsoralen photoadducts in DNA from Fanconi anemia and normal human fibroblasts: quantitative analysis by electron microscopy. J Photochem Photobiol B17: 27-34 (1993).

    34. Gasparro FP, Gattolin P, Olack G, Deckelbaum LI & Sumpio BE. Visible excitation of 8-MOP: HPLC quantitation of monoadducts and crosslinks. Photochem Photobiol 57: 1007-1010 (1993).

    35. Olack GA, Gattolin P & Gasparro FP. Improved HPLC analysis of 8-methoxypsoralen monoadducts and crosslinks in polynucleotide, DNA and cellular systems: Analysis of split-dose protocols. Photochem Photobiol 57: 941-949 (1993).

    36. Sumpio DE, Phan SM, Gasparro FP & Deckelbaum LI. Control of smooth muscle proliferation by psoralen photochemotherapy. J Vasc Surg 17: 1010-1018 (1993).

    37. Havre PA, Gunther EJ, Gasparro FP & Glazer PM. Targeted mutagenesis of DNA using triple helix forming oligonucleotides linked to psoralen. Proc Natl Acad Sci (USA) 90: 7879-7883 (1993).

     38. Gasparro FP, Malane MS, Maxwell VM & Tigelaar RE. The treatment of mastocytoma cells with 8-methoxypsoralen and long wavelength ultraviolet radiation enhances cellular immunogenicity: Preliminary results. Photochem Photobiol 58: 682-688 (1993).

    39. Tokura Y, Edelson RL & Gasparro FP. Modulation of 8-methoxypsoralen-DNA photoadduct formation by cell differentiation, mitogenic stimulation and phorbol ester exposure in murine T lymphocytes. Photochem Photobiol 58: 822-826 (1993).

    40. Gasparro FP, Havre PA, Olack GA, Gunther EJ &Glazer PM. Site-specific targeting of psoralen photoadducts with a triple helix-forming oligonucleotide: Characterization of psoralen monoadduct and crosslink formation. Nucl Acids Res 22: 2845-2852 (1994)

    41. Schmitt I, Maxwell VM, Olack GO, Chimenti S, Edelson RL & Gasparro FP. The specific effects of 8-methoxypsoralen photoadducts on cell survival: HPLC analysis of monoadduct and crosslink formation in cells exposed to split-dose treatment. J Photochem Photobiol B22: 17-21 (1994).

    42. Oroskar A, Olack G, Peak MJ & Gasparro FP. 4'-Aminomethyl-4,5',8-trimethylpsoralen Photochemistry. Photoadduct dependence on concentration and UVA dose in poly(dA-dT) and calf thymus DNA. Photochem Photobiol 60: 567-573 (1994).

    43. Sumpio BE, Li G, Deckelbaum LI & Gasparro FP. Selective inhibition of smooth muscle cell proliferation by visible light activated psoralen. Circulation Research 75: 208-213 (1994).

    44. Spaedy TJ, March KL, Wilensky RL, Aita M, Gasparro FP, Gradus-Pizlo I, Mehdi K & Hathaway DR: The combination of 8-methoxypsoralen and ultraviolet A light inhibit smooth muscle cell proliferation after angioplasty. Circulation (submitted).

    45. Gunther EJ, Yeasky T, Gasparro FP & Glazer PM. Mutagenesis by 8-methoxypsoralen and 5-methylangelicin photoadducts in mouse fibroblasts: Mutations at crosslinkable sites by monoadducts as well as crosslinks. Cancer Research 55: 1283-1288 (1995).

    46. Schmitt IM, Moor ACE, Chimenti S, Beijersbergen van Henegouwen GM, Edelson RL & Gasparro FP. Increased surface expression of class I MHC molecules on non-tumorigenic cells derived from the xenogenization of tumorigenic P815 mastocytoma cells with 8-methoxypsoralen and long wavelength ultraviolet radiation. Tissue Antigens 46: 45-49 (1995).

    47. Moor ACE, Schmitt IM, Beijersbergen van Henegouwen GM, Chimenti S, Edelson RL & Gasparro FP. Treatment of murine lymphoma cells with 8-MOP and UVA enhances MHC class I synthesis. J. Photochem Photobiol B 29: 193-198 (1995).

    48. Gasparro FP. The effect of DNA tertiary structure on 4'-aminomethyl-4,5',8-trimethylpsoralen intercalation and photoadduct formation (submitted).

    49. Bolognia JL, Freije L, Amici L, Dellostritto J & Gasparro FP. Rectal suppositories of 8-methoxypsoralen produce less side effects than the oral formulation. J Am Acad Dermatol 000-000

    50. Amici L & Gasparro FP. 5-Methoxypsoralen photochemistry: Conversion of monoadducts to crosslinks. Photodermatol Photomed Photoimmunol 11: 135-139 (1995).

    51. Gunther EJ, Havre PA, Gasparro FP & Glazer PM. Targeted mutagenesis of mouse genomic DNA in vitro mediated by triple helix formation. Photochem Photobiol 63: 207-212 (1996)

     52. Vowels BR, Yoo EK & Gasparro FP. Kinetic analysis of apoptosis induction in human cells UVA and 8-MOP. Photochem Photobiol 63: 572-576 (1996).

    53. Park J, Amici L & Gasparro FP. Strand dependence for 8-MOP photoadduct formation in complementary oligonucleotides. Photodermatol Photomed Photoimmunol 11: 102-106 (1995).

    54. Van Iperen HP, Brun BM, Caffieri S, Dall=Acqua F, Gasparro FP & Beijersbergen van Henegouwen GMJ. The lack of efficacy of 4,6,4'-trimethylangelicin to induce immune suppression in an animal model for photopheresis: a comparison with 8-methoxypsoralen. Photochem Photobiol 63: 577-52 (1996).

    55. Yoo EK, Rook AH, Elenitsas R, Gasparro FP & Vowels BR. Apoptosis Induction by Photochemotherapy: Relevance to anti-tumor therapy. J Invest Dermatol 107: 235-242 (1996).

    56. Bernstein EF, Gasparro FP, Brown DB, Takeuchi T & Uitto J. 8-Methoxypsoralen and ultraviolet A radiation activate the human elastin promoter in transgenic mice: in vivo and in vitro evidence for gene induction. Photochem Photobiol 64: 369-374 (1996).

    57. Wang XM,Madison-McNiff J, Klump V, Asgari M & Gasparro FP. An unexpected spectrum in p53 mutations from squamous cell carcinomas in patients treated with PUVA. Photochem Photobiol 66: 294-299 (1997) [Rapid Communication].
    1. Uitto J, Brown DB, Gasparro FP & Bernstein EF. Molecular aspects of phtoaging. Eur J Dermatol 7: 210-214 (1997).
    II. Chapters, Reviews, Editorials etc.

    1. Gasparro, FP. An interesting and inexpensive solubility product experiment for general chemistry. J Chem Ed 53: 98 (1976).

    2. Gasparro FP & Kolodny NH. NMR determination of the barrier to rotation in N,N-dimethylacetamide. A physical chemistry experiment. J Chem Ed 54: 389-395 (1976).

    3. Berger CL, Edelson RL, Gasparro FP & Harber LC. Skin-associated lymphoid tissues and photodiseases, theoretical considerations. In Clinical Photoimmunology (eds. Krueger J and Daynes R) CRC Press. Vol II, 167-182 (1983).

    4. Gasparro FP, Song J, Knobler RM & Edelson RL. Quantitation of psoralen photoadducts in DNA isolated from lymphocytes treated with 8-methoxypsoralen and ultraviolet A light (Extracorporeal Photopheresis). In Current Problems in Dermatology 15: 67-84 (1986).

    5. Gasparro FP, Chan G & Edelson RL. Phototherapy and Photopharmacology. Yale J Biol Med 58: 519-534 (1985).

    6. Santella RM, Gasparro FP & Edelson RL. Quantification of methoxsalen-DNA adducts with specific antibodies. In Carcinogenicity of Alkylating Cytostatic Drugs IARC Science Publications 78:127-139 (1986).

    7. Santella RM, Gasparro FP & Ling-Ling H. Quantitation of carcinogen-DNA adducts with monoclonal antibodies (Progress in Experimental Tumor Research).

         8. Bayley H, Gasparro FP & Edelson RL: Light Activated Drugs. Trends in Pharmaceutical Sciences 8: 138-143 (1987).

    9. Gasparro FP. Psoralen-DNA Interactions. In Psoralen-DNA Photobiology (ed. FP Gasparro) CRC Press, vol I, Boca Raton (1988).

    10. Gasparro FP. Immunological assay of 8-MOP photoadducts. J Photochem Photobiol B2: 286-288 (1988).

    11. Gasparro FP & Santella RM. Immunoassay of DNA Damage. Photochem Photobiol 48: 321-328 (1988).

    12. Santella RM, Yang XY, DeLeo VA & Gasparro FP. Detection and quantification of 8-methoxypsoralen-DNA adducts. In DNA Damaging Agents in Humans IARC Science Publications (eds. H Bartsch, K Hemminki & K O'Neill) Lyon 89: 333-340 (1988).

    13. Gasparro FP. PABA: friend or foe? Photodermatol 3: 61-63 (1986) (an invited editorial).

    14. Gasparro FP, Weingold D, Simmons E, Goldminz D & Edelson RL. Quantification of 8-MOP photoadducts in lymphocytes. In Photobiology - The Science and Its Application (ed. E Riklis) Plenum Pres 951-962 (1991).

    15. Gasparro FP, Bevilacqua PM, Goldminz D & Edelson RL. Repair of 8-MOP Photoadducts in Human Lymphocytes. In DNA Damage and Repair in Human Cells (eds. BM Sutherland & AD Woodhead) Plenum Press (1990) 137-154.

    16. Gasparro FP, Dall'Amico R, Goldminz D, Simmons E & Weingold D. Molecular Aspects of Photopheresis. Yale J Biol Med 62: 579-593 (1989).

    17. Gasparro FP. 8-MOP Photochemotherapy: Perspectives and Prospects. SPIE Institute on Photodynamic Therapy, Vol IS6: 195-204 (1990).

    18. Gasparro FP. An action spectrum for the elicitation of erythema in skin persistently sensitized by photobound 8-methoxypsoralen. J Invest Dermatol 96: 799 (1991) (letter)

    19. Malane M & Gasparro FP. T cell molecular targets. Ann NY Acad Sci 666: 354-371 (1991).

    20. Gasparro FP. Sunscreens - A Photochemical perspective. In Photobiology - The Science and Its Application (ed. E Riklis) Plenum Pres 951-62 (1991).

    21. Taylor A & Gasparro FP. Extracorporeal photochemotherapy for CTCL and other diseases. Sem in Hematol (eds. Jaffe & Deeg) 29:132-41 (1992).

    22. Gasparro FP. The molecular basis of UV-induced mutagenicity of sunscreens. FEBS 336: 184-185 (1993) (commentary).

    23. Gasparro FP. Mood Indigo. The Sciences. July/August (1993) page 47 (letter).

    24. Gasparro FP. Novel approaches to tailoring psoralen use to phototherapeutic need. Current Opinion in Dermatology 2: 167-172 (1995). Invited review

    25. Gasparro FP. Extracorporeal Photochemotherapy. In Photoimmunology Update (eds. J Krutman & C Elmets) (1995).

         26. Gasparro FP. 8-Methoxypsoralen molecular biology. In CRC Handbook of Photochemistry (ed. P-S Song) (1995).

    27. Schmitt IM, Chimenti S & Gasparro FP. Psoralen-protein photochemistry - the forgotten field. J Photochem Photobiol B: Biol 27: 101-107 (1995). Invited review

    28. Gasparro FP, Felli A & Schmitt IM. Psoralen photobiology: The relationship between DNA damage, chromatin structure, transcription and immunogenic effects in >Risk and Progression Factors in Carcinogenesis= (eds., HK Müller-Hermelink, H-H Neumann, W Dekant) Recent Results in Cancer Research 143: 101-127 (1997).

    29. Moor ACE & Gasparro FP. Biochemical Aspects of Psoralen Photochemotherapy. Clinics in Dermatology 14: 353-365 (1996). Invited review

    30. Schmitt IM, DeLeo KD, Wang XM & Gasparro FP. Photobiology of Psoralens (ed. Honigsmann H) (1996).

    31. Gasparro FP. Psoralen Photobiology - Recent Advances. Photochem Photobiol 63: 553-557 (1996). Invited review
    1. Gasparro FP, Liao B, Foley PJ, Wang XM & Madison McNiff J. Psoralen Photochemotherapy, Clinical Efficacy and Photomutagenicity: The Role of Molecular Epidemiology in Minimizing Risks. Environ Mol Mutagen 31: 105-112 (1998). Invited review
    2. Gasparro FP, p53 in Dermatology, Archives of Dermatology 133: 1029-1032 (1998). Invited editorial
    3. Gasparro FP, Foley PJ & Bethea BM. APsoralens@ entry for new edition of the Encyclopedia of Molecular Biology (John Wiley & Sons, NY NY 1999)
    INVITED PRESENTATIONS

    1983

    1. "Action-Spectra for Psoralen-DNA Crosslinking"

    University of Padua.

    1985

    1. "8-MOP Photobiology and Photochemotherapy" Albert Einstein College of Medicine. 2. "Wavelength Dependence for Psoralen Crosslinking" Curie Institute (Paris). 3. "Wavelength Dependence for Psoralen Crosslinking" University of Vienna. 1986 1. "Immunoassay for the detection of 8-MOP Photoadducts

    Round table "Determination of DNA Lesions" European Society for Photobiology.

    2. Visiting Scientist, September 1986 - University of Austria.

         1987 1. "Immunoassay of DNA Damage" DNA Repair Symposium, American Society for Photobiology. 2. "Extracorporeal Photochemotherapy of CTCL" SPIE Symposium: New Directions in Photodynamic Therapy. 3. "Opportunities and Pitfalls - Detection of 8-MOP Photoadducts" University Medical and Dental College, Newark, New Jersey. 1988 1. "Quantification of 8-MOP Photoadducts in Lymphocyte" Symposium 10th International Congress of Photobiology. 2. "Sunscreens - A Photochemical Perspective" Symposium 10th International Congress of Photobiology. 3. "Effects of 8-MOP and UVA on Lymphocytes" Workshop: Correlation of In vitro and in vivo Effects. American Society for Photobiology. 4. "8-MOP-DNA Photobiology" Photomedicine Lab, Harvard University. 5. "Photopheresis - Clinical Results and Basis for Response" Pediatrics, University of Padua. 6. "8-MOP/UVA Photochemotherapy" Pharmaceutical Sciences, University of Padua. 1989 1. "Photoactivatable Antisense DNA" Psoralen Symposium: American Society for Photobiology. 2. "Psoralen Photobiology - New Aspects: Photoactivatable Antisense DNA" Pharmaceutical Sciences, University of Padua. 3. "Extracorporeal Photochemotherapy with 8-MOP and UVA" Cancer Center, Northwestern University. 4. "Repair of 8-MOP Photoadducts in Human Lymphocytes" Symposium: DNA Damage and Repair in Human Tissue, Brookhaven National Laboratory 5. "Photopheresis - Survey of Clinical Results" Department of Dermatology, University of Pavia. 1990 1. "Psoralen Photochemotherapy - Perspective and Prospects" SPIE Symposium: Future Directions and Applications of Photodynamic Therapy. 2. "Extracorporeal Photochemotherapy: A Molecular Mechanism"

    Department of Dermatology, University of Oregon Health Sciences.

         1991

    1. "Photoactivatable Antisense DNA"

    Division of Medical Research, Argonne National Laboratory. 2. "Photoactivatable Antisense DNA"

    Symposium: American Society for Photobiology.

    3. "Extracorporeal Photochemotherapy - Cell Death vs. Immune Effects"

    Division of Oncology: Hilton Head Hospital.

    4. "PUVA: Tricks of the Trade"

    Department of Dermatology, State University of New York, Valhalla.

     1992 1. "8-MOP/UVA Extracorporeal Photochemotherapy - Mechanism of Action"

    Photomedicine Lab, Harvard University.

    2. "Photopheresis - Molecular Aspects: Cell Death vs. Immune Stimulation"

    Hilton Head Hospital Symposium on Photopheresis. 3. "Extracorporeal Photochemotherapy - Molecular Mechanism Underlying Clinical Response"

    Cancer and Blood Diseases - Medical College of Wisconsin.

    4. "Photoactivatable Antisense DNA and Other Antisense Strategies"

     Evan & Marion Helfaer Lectureship, Medical College of Wisconsin.

    5. "Sunscreens - An Overview"

    Symposium: American Society for Photobiology.

     6. 8-MOP Photochemotherapy"

    Department of Dermatology, Columbia Presbyterian Medical Center.

    1993

    1. "8-Methoxypsoralen Photochemotherapy"

    Department of Dermatology, University of Pennsylvania.

    2. "New Aspect of Psoralen Photochemotherapy"

    Symposium: DERM2000 International Meeting, Vienna Austria.

    3. "The Role of Psoralen Monoadducts and Crosslinks in Cytotoxicity"

    Symposium: American Society for Photobiology.

    4. "Novel Aspects of Psoralen Photobiology & Photoimmunology" New York Blood Center.

    1994

    1. "Non-cytotoxic Effects of Chemotherapeutic Agents"

    Cancer Immunobiology Laboratory, Hilton Head Hospital.

    2. "Sunscreen Round Table" Chair, ASP Annual Meeting

    1995

    1. AThe Role of p53 in Photochemotherapy@ (Photomedicine Society, February) New Orleans, LA 2. ADo Responses in Photochemotherapy Patients Result from the Concerted Effects of Transcription Factor Induction and Adduct Repair?@ (Keystone Symposium, April). 3. APsoralen Photobiology@ Department of Dermatology (Thomas Jefferson University) 3. APsoralen Photobiology - Are the Mutagenic and Immunogenic Effects Related@ (>Sonderforschungbereich=, University of Wurzburg, May 1995)

    4. AWhat is Photobiology@ (Chair, Workshop for Congressional Science Aides, Media etc,)

     1995 ASP Meeting, June. 5. AThe Consequences of Psoralen Photochemistry in Mammalian Cells@ (Chair, Symposium) 1995 ASP Meeting, June

    1996

    1. AApoptosis and Photochemotherapy@ (12th International Congress of Photobiology, Vienna Austria September).
    2. AThe Role of Apoptosis in the Response of Patients to Photopheresis@ (Molecular Medicine Seminar Series, Thomas Jefferson University, October).

      3.  

       
       
       
       
       
       
       
       
       
       
       

      1997

    3. APhotomutagenicity - Psoralen as an Example@ (Annual Meeting of the Environmental Mutagen Society, Minneapolis, April 21).
    4. APhototherapy - Basic Principles@ (Bioptron Seminar, NY, April 30)
    5. APhototherapy for the Prevention of Restenosis@ (Annual Meeting of the European Society for Photobiology,
    Stresa Italy, September 12).
    1. AUnexpected p53 Mutation Spectrum in PUVA SCC@ (October 14, Harvard University, Department of Dermatology)
    2. ATargeted Photochemistry in Oligonucleotides of Defined Sequences@ (October 15, Boston University, Department of Dermatology)
    1998

    1. AVariations in 8-MOP Plasma Levels@ (Hawaiian Dermatology Seminar, Hawaii, January 30)

    2. AUV Exposure and Skin Cancer - Consensus and Controversy@ (American Academy of Dermatology, Orlando FL, February 28)

    1. ASunburn as a Surrogate Marker of Later Biologic Events@, Session Chair at NIH Workshop on Risks and Benefits of Exposure to Ultraviolet Radiation and Tanning, Bethesda MD<,September 16-18).
    Upcoming Invited Lectures
    1. APrinciples of Cutaneous Photobiology@ (American Academy of Dermatology, New Orleans LA, March 19).
    2. ASunscreens: Basic Properties, Assessment of UVB and UVA Protective Factors@ (American Academy of Dermatology, New Orleans LA, March 19).
    3. APsoralen Photobiology - Clinical Implications of the Science@ (Advances in the Biology and Treatment of the Skin, Rutgers University, June 24)
    4. Skin Cancer Action Spectra - known and need to be known (27th Annual meeting of the American Society for Photobiology, Washington DC July 13)
    5. Sunscreen Photobiology - Dickinson College, Carlisle PA (November 19)
    OTHER ABSTRACTS 1. Edelson RL, Berger CL, Gasparro FP, Lee K & Taylor J. Treatment of leukemic T-cell lymphoma with extracorporeally activated 8-methoxypsoralen, Clin Res 31: 467 A, (1983).

    2. Bisaccia E, Berger CL, Murphy R, Gasparro FP, Patterson JAK & Edelson RL. Internalization of insulin by activated human T-cells, Clin Res 31: 467 A, (1983).

    3 Heald P, Latkowski J, Gasparro FP, Yan SL & Edelson RL. Specific suppression of T-cell surface antigens with antisense oligodeoxynucleotides, J Invest Dermatol 94: 533 A (1990).

     PROFESSIONAL SOCIETIES

    13th Internal Congress on Photobiology (President)

    American Society for Photobiology (President 1995-1998)

    Society of Investigative Dermatology

    American Chemical Society

    Photomedicine Society

    American Association for the Advancement of Science

    European Society for Photobiology

    New York Academy of Sciences

    PROFESSIONAL DUTIES

    President: American Society for Photobiology (1996-1998)

    President: Organizing Committee for Photobiology 2000 (13th International Congress of Photobiology)

    Photobiology Section Editor: Journal of Investigative Dermatology (July 1997)

    Editorial Board: Photodermatology, Photomedicine and Photoimmunology Reviewer: PNAS; Photodermatology, Photomedicine and Photoimmunology; Photochemistry & Photobiology

    RESEARCH GRANTS

    NIH FIRST Award (1/1/86-12/31/90): Characterization of Psoralen DNA Photoadducts.

    American Cancer Society (Yale University CCC). Adenine Dehydrodimer Formation.

    New York Cardiac Center (11/1/90-10/31/93)

    NIH Skin Disease Research Center - Pilot/Feasibility Project (9/92-8/94)

    Illumenex Corporation (2/93-2/94)

    Therakos INC (Mechanistic Aspects of Photopheresis, 4/97-3/98) American Cancer Society (Psoralen Photoadduct Mutagenesis) (7/96-6/99)

    NIH (p53 Mutations in PUVA SCC) (pending)

    OTHER GRANTS

    Research Corporation 1978-79

    Colgate University Research Council 1978

    Union Carbide Corporation 1978

    Union Carbide Corporation 1979
     
     

    HONORS AND AWARDS

    Faculty Research Award, Wellesley College, 1973-1974.

    Public Health Services Fellow (NIH), Princeton University, 1968-1970.

    Full Tuition Scholarship to Villanova University, 1962-1966.

    HOBBIES

    Tennis

    Photography

    Model Railroading

    Web Page Authoring